Novel drug development opportunities for heparin
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd724.pdf
Reference117 articles.
1. Turnbull, J., Powell, A. & Guimond, S. Heparan sulfate: decoding a dynamic multifunctional cell regulator. Trends Cell Biol. 11, 7582 (2001).An excellent review on the role of heparan sulphate as a regulatory molecule, with reference to specific structural features and their relevance in protein binding.
2. Vlodavsky, I. & Friedmann, Y. Molecular properties and involvement of heparanase in cancer metastasis and angiogenesis. J. Clin. Invest. 108, 341347 (2001).
3. Tyrrell, D. J. et al. Heparin in inflammation: potential therapeutic applications beyond anticoagulation. Adv. Pharmacol. 46, 151208 (1999).A comprehensive review of the literature concerning the non-anticoagulant effects of heparin with an emphasis on its anti-inflammatory actions.
4. McLean, J. The thromboplastic action of cephalin. Am. J. Physiol. 41, 250 (1916).
5. Rosenberg, J. S., McKenna, P. W. & Rosenberg, R. D. Inhibition of human factor IXa by human antithrombin. J. Biol. Chem. 250, 88838888 (1975).
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