Inhibition of RAS function through targeting an allosteric regulatory site-Reference-Cited by-同舟云学术

Inhibition of RAS function through targeting an allosteric regulatory site

Published:2016-11-07 Issue:1 Volume:13 Page:62-68
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Spencer-Smith Russell,Koide Akiko,Zhou Yong,Eguchi Raphael R,Sha Fern,Gajwani Priyanka,Santana Dianicha,Gupta Ankit,Jacobs Miranda,Herrero-Garcia Erika,Cobbert Jacqueline,Lavoie Hugo,Smith Matthew,Rajakulendran Thanashan,Dowdell Evan,Okur Mustafa Nazir,Dementieva Irina,Sicheri Frank,Therrien Marc,Hancock John F,Ikura Mitsuhiko,Koide Shohei,O'Bryan John P

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.2231.pdf

Reference60 articles.

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3. Ostrem, J.M., Peters, U., Sos, M.L., Wells, J.A. & Shokat, K.M. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature 503, 548–551 (2013).

4. Leshchiner, E.S. et al. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proc. Natl. Acad. Sci. USA 112, 1761–1766 (2015).

5. Patgiri, A., Yadav, K.K., Arora, P.S. & Bar-Sagi, D. An orthosteric inhibitor of the Ras-Sos interaction. Nat. Chem. Biol. 7, 585–587 (2011).

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