A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models-Reference-Cited by-同舟云学术

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

Published:2015-04-27 Issue:6 Volume:11 Page:432-437
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Chan-Penebre Elayne,Kuplast Kristy G,Majer Christina R,Boriack-Sjodin P Ann,Wigle Tim J,Johnston L Danielle,Rioux Nathalie,Munchhof Michael J,Jin Lei,Jacques Suzanne L,West Kip A,Lingaraj Trupti,Stickland Kimberly,Ribich Scott A,Raimondi Alejandra,Scott Margaret Porter,Waters Nigel J,Pollock Roy M,Smith Jesse J,Barbash Olena,Pappalardi Melissa,Ho Thau F,Nurse Kelvin,Oza Khyati P,Gallagher Kathleen T,Kruger Ryan,Moyer Mikel P,Copeland Robert A,Chesworth Richard,Duncan Kenneth W

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.1810.pdf

Reference51 articles.

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2. Wang, L., Pal, S. & Sif, S. Protein arginine methyltransferase 5 suppresses the transcription of the RB family of tumor suppressors in leukemia and lymphoma cells. Mol. Cell. Biol. 28, 6262–6277 (2008).

3. Pal, S. et al. Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. EMBO J. 26, 3558–3569 (2007).

4. Wei, T.-Y.W. et al. Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci. 103, 1640–1650 (2012).

5. Powers, M.A., Fay, M.M., Factor, R.E., Welm, A.L. & Ullman, K.S. Protein arginine methyltransferase 5 accelerates tumor growth by arginine methylation of the tumor suppressor programmed cell death 4. Cancer Res. 71, 5579–5587 (2011).

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