Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A-Reference-Cited by-同舟云学术

Targeting S-adenosylmethionine biosynthesis with a novel allosteric inhibitor of Mat2A

Published:2017-05-29 Issue:7 Volume:13 Page:785-792
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Quinlan Casey L^ORCID,Kaiser Stephen E,Bolaños Ben,Nowlin Dawn,Grantner Rita,Karlicek-Bryant Shannon,Feng Jun Li,Jenkinson Stephen,Freeman-Cook Kevin,Dann Stephen G,Wang Xiaoli,Wells Peter A,Fantin Valeria R,Stewart Al E,Grant Stephan K

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.2384.pdf

Reference43 articles.

1. Timp, W. & Feinberg, A.P. Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nat. Rev. Cancer 13, 497–510 (2013).

2. Lu, S.C. & Mato, J.M. S-adenosylmethionine in liver health, injury, and cancer. Physiol. Rev. 92, 1515–1542 (2012).

3. Halim, A.B., LeGros, L., Geller, A. & Kotb, M. Expression and functional interaction of the catalytic and regulatory subunits of human methionine adenosyltransferase in mammalian cells. J. Biol. Chem. 274, 29720–29725 (1999).

4. Kotb, M. & Kredich, N.M. Regulation of human lymphocyte S-adenosylmethionine synthetase by product inhibition. Biochim. Biophys. Acta 1039, 253–260 (1990).

5. LeGros, H.L. Jr., Geller, A.M. & Kotb, M. Differential regulation of methionine adenosyltransferase in superantigen and mitogen stimulated human T lymphocytes. J. Biol. Chem. 272, 16040–16047 (1997).

Cited by 91 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. MAT2A is essential for zygotic genome activation by maintaining of histone methylation in porcine embryos;Theriogenology;2024-12

2. Inhibition of MAT2A Impairs Skeletal Muscle Repair Function;Biomolecules;2024-09-02

3. Epigenome-wide impact of MAT2A sustains the androgen-indifferent state and confers synthetic vulnerability in ERG fusion-positive prostate cancer;Nature Communications;2024-08-06

4. Metabolic reprogramming in tumor immune microenvironment: Impact on immune cell function and therapeutic implications;Cancer Letters;2024-08

5. Structure-Based Design and Optimization of Methionine Adenosyltransferase 2A (MAT2A) Inhibitors with High Selectivity, Brain Penetration, and In Vivo Efficacy;Journal of Medicinal Chemistry;2024-05-31