Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila-Reference-Cited by-同舟云学术

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Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila

Published:2008-03-09 Issue:4 Volume:4 Page:256-263
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Chang Shuang,Bray Steven M,Li Zigang,Zarnescu Daniela C,He Chuan,Jin Peng,Warren Stephen T

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.78.pdf

Reference50 articles.

1. Penagarikano, O., Mulle, J.G. & Warren, S.T. The pathophysiology of fragile x syndrome. Annu. Rev. Genomics Hum. Genet. 8, 109–129 (2007).

2. Feng, Y. et al. FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association. Mol. Cell 1, 109–118 (1997).

3. Todd, P.K., Mack, K.J. & Malter, J.S. The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95. Proc. Natl. Acad. Sci. USA 100, 14374–14378 (2003).

4. Brown, V. et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107, 477–487 (2001).

5. Darnell, J.C. et al. Fragile X mental retardation protein targets G quartet mRNAs important for neuronal function. Cell 107, 489–499 (2001).

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