High-content single-cell drug screening with phosphospecific flow cytometry
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nchembio.2007.59.pdf
Reference42 articles.
1. Nicholson, R.L., Welch, M., Ladlow, M. & Spring, D.R. Small-molecule screening: advances in microarraying and cell-imaging technologies. ACS Chem. Biol. 2, 24–30 (2007).
2. Valet, G. Cytomics as a new potential for drug discovery. Drug Discov. Today 11, 785–791 (2006).
3. Lang, P., Yeow, K., Nichols, A. & Scheer, A. Cellular imaging in drug discovery. Nat. Rev. Drug Discov. 5, 343–356 (2006).
4. Nolan, G.P. What's wrong with drug screening today. Nat. Chem. Biol. 3, 187–191 (2007).
5. Chow, S., Patel, H. & Hedley, D.W. Measurement of MAP kinase activation by flow cytometry using phospho-specific antibodies to MEK and ERK: potential for pharmacodynamic monitoring of signal transduction inhibitors. Cytometry 46, 72–78 (2001).
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