Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins-Reference-Cited by-同舟云学术

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Small-molecule hydrophobic tagging–induced degradation of HaloTag fusion proteins

Published:2011-07-03 Issue:8 Volume:7 Page:538-543
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Neklesa Taavi K,Tae Hyun Seop,Schneekloth Ashley R,Stulberg Michael J,Corson Timothy W,Sundberg Thomas B,Raina Kanak,Holley Scott A,Crews Craig M

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.597.pdf

Reference43 articles.

1. Overington, J.P., Al-Lazikani, B. & Hopkins, A.L. How many drug targets are there? Nat. Rev. Drug Discov. 5, 993–996 (2006).

2. Russ, A.P. & Lampel, S. The druggable genome: an update. Drug Discov. Today 10, 1607–1610 (2005).

3. Dixon, S.J. & Stockwell, B.R. Identifying druggable disease-modifying gene products. Curr. Opin. Chem. Biol. 13, 549–555 (2009).

4. Crews, C.M. Targeting the undruggable proteome: the small molecules of my dreams. Chem. Biol. 17, 551–555 (2010).

5. Luo, J. et al. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835–848 (2009).

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