Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition-Reference-Cited by-同舟云学术

Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition

Published:2013-06-02 Issue:8 Volume:9 Page:507-513
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Marzian Stefanie,Stansfeld Phillip J,Rapedius Markus,Rinné Susanne,Nematian-Ardestani Ehsan,Abbruzzese Jennifer L,Steinmeyer Klaus,Sansom Mark S P,Sanguinetti Michael C,Baukrowitz Thomas,Decher Niels

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.1271.pdf

Reference37 articles.

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3. Payandeh, J., Scheuer, T., Zheng, N. & Catterall, W.A. The crystal structure of a voltage-gated sodium channel. Nature 475, 353–358 (2011).

4. Ragsdale, D.S., McPhee, J.C., Scheuer, T. & Catterall, W.A. Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. Proc. Natl. Acad. Sci. USA 93, 9270–9275 (1996).

5. Ragsdale, D.S., McPhee, J.C., Scheuer, T. & Catterall, W.A. Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science 265, 1724–1728 (1994).

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