Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA-Reference-Cited by-同舟云学术

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

Published:2014-05-18 Issue:7 Volume:10 Page:574-581
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Pfaffeneder Toni,Spada Fabio,Wagner Mirko,Brandmayr Caterina,Laube Silvia K,Eisen David,Truss Matthias,Steinbacher Jessica,Hackner Benjamin,Kotljarova Olga,Schuermann David,Michalakis Stylianos,Kosmatchev Olesea,Schiesser Stefan,Steigenberger Barbara,Raddaoui Nada,Kashiwazaki Gengo,Müller Udo,Spruijt Cornelia G,Vermeulen Michiel,Leonhardt Heinrich,Schär Primo,Müller Markus,Carell Thomas

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.1532.pdf

Reference54 articles.

1. Smith, Z.D. & Meissner, A. DNA methylation: roles in mammalian development. Nat. Rev. Genet. 14, 204–220 (2013).

2. Franchini, D.M., Schmitz, K.M. & Petersen-Mahrt, S.K. 5-Methylcytosine DNA demethylation: more than losing a methyl group. Annu. Rev. Genet. 46, 419–441 (2012).

3. Tahiliani, M. et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 324, 930–935 (2009).

4. Pfaffeneder, T. et al. The discovery of 5-formylcytosine in embryonic stem cell DNA. Angew. Chem. Int. Ed. Engl. 50, 7008–7012 (2011).

5. Ito, S. et al. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 333, 1300–1303 (2011).

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