Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases-Reference-Cited by-同舟云学术

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Published:2008-10-12 Issue:11 Volume:4 Page:691-699
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Apsel Beth,Blair Jimmy A,Gonzalez Beatriz,Nazif Tamim M,Feldman Morri E,Aizenstein Brian,Hoffman Randy,Williams Roger L,Shokat Kevan M,Knight Zachary A

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.117.pdf

Reference47 articles.

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3. Shaw, R.J. & Cantley, L.C. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441, 424–430 (2006).

4. Samuels, Y. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554 (2004).

5. Samuels, Y. & Velculescu, V.E. Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 3, 1221–1224 (2004).

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