Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancer

Author:

Moinfar Farid,Beham Alfred,Friedrich Gerhard,Deutsch Alexander,Hrzenjak Andelko,Luschin Gero,Tavassoli Fattaneh A

Publisher

Springer Science and Business Media LLC

Subject

Pathology and Forensic Medicine

Reference37 articles.

1. Moinfar F, Man YG, Arnould L, et al. Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res 2000;60:2562–2566.

2. Kurose K, Hoshaw-Woodard S, Adeyinka A, et al. Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumor microenvironment interactions. Hum Mol Genet 2001;10:1907–1913.

3. Wernert N, Löcherbach C, Wellmann A, et al. Presence of genetic alterations in microdissected stroma of human colon and breast cancers. Anticancer Res 2001;21:2259–2268.

4. Kurose K, Gilley K, Matsumoto S, et al. Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet 2002;32:355–357.

5. Fukino K, Shen L, Matsumoto S, et al. Combined total genome loss of heterozygosity scan of breast cancer stroma and epithelium reveals multiplicity of stromal targets. Cancer Res 2004;64:7231–7236.

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