MDM2 promoter variation and age of diagnosis of acute lymphoblastic leukemia
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Cancer Research,Hematology
Link
http://www.nature.com/articles/2403941.pdf
Reference8 articles.
1. McNeil DE, Cote TR, Clegg L, Mauer A . SEER update of incidence and trends in pediatric malignancies: acute lymphoblastic leukemia. Med Pediatr Oncol 2002; 39: 554–557, discussion 552–553.
2. Wada M, Bartram CR, Nakamura H, Hachiya M, Chen DL, Borenstein J et al. Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood. Blood 1993; 82: 3163–3169.
3. Gustafsson B, Axelsson B, Gustafsson B, Christensson B, Winiarski J . MDM2 and p53 in childhood acute lymphoblastic leukemia: higher expression in childhood leukemias with poor prognosis compared to long-term survivors. Pediatr Hematol Oncol 2001; 18: 497–508.
4. Marks DI, Kurz BW, Link MP, Ng E, Shuster JJ, Lauer SJ et al. Altered expression of p53 and mdm-2 proteins at diagnosis is associated with early treatment failure in childhood acute lymphoblastic leukemia. J Clin Oncol 1997; 15: 1158–1162.
5. Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell 2004; 119: 591–602.
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