Gemtuzumab ozogamicin in pediatric CD33-positive acute lymphoblastic leukemia: first clinical experiences and relation with cellular sensitivity to single agent calicheamicin

Author:

Zwaan ChM,Reinhardt D,Jürgens H,Huismans D R,Hählen K,Smith O P,Biondi A,Wering E R van,Feingold J,Kaspers G J L

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference6 articles.

1. Sievers EL, Appelbaum FR, Spielberger RT, Forman SJ, Flowers D, Smith FO, Shannon-Dorcy K, Berger MS, Bernstein ID . Selective ablation of acute myeloid leukemia using antibody-targeted chemotherapy: a phase I study of an anti-CD33 calicheamicin immunoconjugate. Blood 1999; 93: 3678–3684.

2. Sievers EL, Larson RA, Stadtmauer EA, Estey E, Lowenberg B, Dombret H, Karanes C, Theobald M, Bennett JM, Sherman ML, Berger MS, Eten CB, Loken MR, Van Dongen JJ, Bernstein ID, Appelbaum FR . Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse. J Clin Oncol 2001; 19: 3244–3254.

3. Putti MC, Rondelli R, Cocito MG, Arico M, Sainati L, Conter V, Guglielmi C, Cantu-Rajnoldi A, Consolini R, Pession A, Zanesco L, Masera G, Biondi A, Basso G . Expression of myeloid markers lacks prognostic impact in children treated for acute lymphoblastic leukemia: Italian experience in AIEOP-ALL 88–91 studies. Blood 1998; 92: 795–801.

4. Hinman LM, Hamann PR, Wallace R, Menendez AT, Durr FE, Upeslacis J . Preparation and characterization of monoclonal antibody conjugates of the calicheamicins: a novel and potent family of antitumor antibiotics. Cancer Res 1993; 53: 3336–3342.

5. Zwaan ChM, Kaspers GJL, Pieters R, Ramakers-Van Woerden NL, Den Boer ML, Wnsche R, Rottier MMA, HΩhlen K, Van Wering ER, Janka-Schaub GE, Creutzig U, Veerman AJP . Cellular drug resistance profiles in childhood acute myeloid leukemia: differences between FAB-types and comparison with acute lymphoblastic leukemia. Blood 2000; 96: 2879–2886.

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