Differential gene expression in hematopoietic progenitors from paroxysmal nocturnal hemoglobinuria patients reveals an apoptosis/immune response in ‘normal’ phenotype cells

Author:

Chen G,Zeng W,Maciejewski J P,Kcyvanfar K,Billings E M,Young N S

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference38 articles.

1. Hall C, Richards SJ, Hillmen P . The glycosylphosphatidylinositol anchor and paroxysmal nocturnal haemoglobinuria/aplasia model. Acta Haematol 2002; 108: 219–230.

2. Rosse W . A brief history of PNH. In: Young NS, Moss J (eds). PNH and the GPI-linked Proteins. San Diego: Academic Press, 2000, pp 1–20.

3. Okuda K, Kanamaru A, Ueda E, Kitani T, Okada N, Okada H et al. Expression of decay-accelerating factor on hematopoietic progenitors and their progeny cells grown in cultures with fractionated bone marrow cells from normal individuals and patients with paroxysmal nocturnal hemoglobinuria. Exp Hematol 1990; 18: 1132–1136.

4. Dunn DE, Yu J, Nagarajan S, Devetten M, Weichold FF, Medof ME et al. A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(−) hematopoiesis is reconstituted following intercellular transfer of GPI- anchored proteins. PNAS 1996; 93: 7938–7943.

5. Rosti V, Tremmi G, Scares V, Pandolfi PP, Luzzatto L, Bessler M . Murine embryonic stem cells without pig-a gene activity are competent for hematopoiesis with the PNH phenotype but not for clonal expansion. J Din Invest 1997; 100: 1028–1036.

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