Acquisition of FLT3 or N-ras mutations is frequently associated with progression of myelodysplastic syndrome to acute myeloid leukemia

Author:

Shih L-Y,Huang C-F,Wang P-N,Wu J-H,Lin T-L,Dunn P,Kuo M-C

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference46 articles.

1. Mufti GJ, Galton DA . Myelodysplastic syndromes: natural history and features of prognostic importance. Clin Haematol 1986; 15: 953–971.

2. Raskind WH, Steinmann L, Najfeld V . Clonal development of myeloproliferative disorders: clues to hematopoietic differentiation and multistep pathogenesis of cancer. Leukemia 1998; 12: 108–116.

3. Lai JL, Preudhomme C, Zandecki M, Flactif M, Vanrumbeke M, Lepelley P et al. Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoiesis and a high incidence of P53 mutations. Leukemia 1995; 9: 370–381.

4. Kaneko H, Misawa S, Horiike S, Nakai H, Kashima K . TP53 mutations emerge at early phase of myelodysplastic syndrome and are associated with complex chromosomal abnormalities. Blood 1995; 85: 2189–2193.

5. Quesnel B, Guillerm G, Vereecque R, Wattel E, Preudhomme C, Bauters F et al. Methylation of the p15INK4b gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood 1998; 91: 2985–2990.

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