Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells-Reference-Cited by-同舟云学术

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Synergy between an IGF-1R antibody and Raf/MEK/ERK and PI3K/Akt/mTOR pathway inhibitors in suppressing IGF-1R-mediated growth in hematopoietic cells

Published:2006-04-27 Issue:7 Volume:20 Page:1254-1260
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Bertrand F E,Steelman L S,Chappell W H,Abrams S L,Shelton J G,White E R,Ludwig D L,McCubrey J A

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/2404217.pdf

Reference22 articles.

1. Gleenie MJ, Johnson PWM . Clinical trials of antibody therapy. Immunol Today 2000; 21: 403–410.

2. Ross JS, Gray K, Gray GS, Worland PJ, Rolfe M . Anti-cancer antibodies. Am J Clin Pathol 2003; 119: 472–485.

3. Lu D, Zhang H, Ludwig D, Persaud A, Jimenez X, Burtrum D et al. Simultaneous blockage of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully recombinant bispecific antibody. J Biol Chem 2004; 279: 2856–2865.

4. Mitsiades CS, Mitsiades NS, McMullan CJ, Poulaki V, Shringarpure R, Akiyama M et al. Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors. Cancer Cell 2004; 5: 221–230.

5. Cohen BD, Baker DA, Soderston C, Tkalcevic G, Rossi AM, Miller PE et al. Combination therapy enhances the inhibition of tumor growth with the fully human anti-type 1 insulin like growth factor receptor monoclonal antibody CP-751,871. Clin Cancer Res 2005; 11: 2063–2073.

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