VEGF/PLGF induces leukemia cell migration via P38/ERK1/2 kinase pathway, resulting in Rho GTPases activation and caveolae formation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Oncology,Cancer Research,Hematology
Link
http://www.nature.com/articles/2404668.pdf
Reference8 articles.
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2. Santos SC, Dias S . Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signalling pathways. Blood 2004; 103: 3883–3889.
3. Bellamy WT, Richter L, Sirjani D, Roxas C, Glinsmann-Gibson B, Frutiger Y et al. Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes. Blood 2001; 97: 1427–1434.
4. Fragoso R, Pereira T, Wu Y, Zhu Z, Cabeçadas J, Dias S . VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease. Blood 2006; 107: 1608–1616.
5. Dias S, Shmelkov SV, Lam G, Raffi S . VEGF165 promotes survival of leukemic cells by Hsp90-mediated inductin of Bxl-2 expression and apoptosis inhibition. Blood 2002; 99: 2532–2540.
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