Synthetic triterpenoids activate a pathway for apoptosis in AML cells involving downregulation of FLIP and sensitization to TRAIL

Author:

Suh W-S,Kim Y S,Schimmer A D,Kitada S,Minden M,Andreeff M,Suh N,Sporn M,Reed J C

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference44 articles.

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2. Makin G, Hickmann JA . Apoptosis and cancer chemotherapy. Cell Tissue Res 2000; 301: 143.

3. Honda T, Rounds BV, Gribble GW, Suh N, Wang Y, Sporn MB . Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophages. Bioorg Med Chem Lett 1998; 8: 2711–2714.

4. Suh N, Honda T, Finlay HJ, Barchowsky A, Williams C, Benoit NE et al. Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages. Cancer Res 1998; 58: 717–723.

5. Suh N, Wang Y, Honda T, Gribble GW, Dmitrovsky E, Hickey WF et al. A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activity. Cancer Res 1999; 59: 336–341.

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