Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/srep21248.pdf
Reference45 articles.
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2. Acosta, C. et al. TREK2 expressed selectively in IB4-binding C-fiber nociceptors hyperpolarizes their membrane potentials and limits spontaneous pain. J Neurosci 34, 1494–1509 (2014).
3. Pereira, V. et al. Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception. Pain 155, 2534–2544 (2014).
4. Xiao, Z. et al. Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer’s disease model. J Neurosci 34, 7027–7042 (2014).
5. Xiao, Z. et al. Noradrenergic depression of neuronal excitability in the entorhinal cortex via activation of TREK-2 K+ channels. J Biol Chem 284, 10980–10991 (2009).
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