Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF-Reference-Cited by-同舟云学术

Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF

Published:2010-10 Issue:10 Volume:16 Page:1147-1151
ISSN:1078-8956
Container-title:Nature Medicine
language:en
Short-container-title:Nat Med

Author:

Quigley Michael,Pereyra Florencia,Nilsson Björn,Porichis Filippos,Fonseca Catia,Eichbaum Quentin,Julg Boris,Jesneck Jonathan L,Brosnahan Kathleen,Imam Sabrina,Russell Kate,Toth Ildiko,Piechocka-Trocha Alicja,Dolfi Douglas,Angelosanto Jill,Crawford Alison,Shin Haina,Kwon Douglas S,Zupkosky Jennifer,Francisco Loise,Freeman Gordon J,Wherry E John,Kaufmann Daniel E,Walker Bruce D,Ebert Benjamin,Haining W Nicholas

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

http://www.nature.com/articles/nm.2232.pdf

Reference30 articles.

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2. Barber, D.L. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682–687 (2006).

3. Blackburn, S.D. et al. Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection. Nat. Immunol. 10, 29–37 (2009).

4. Riley, J.L. PD-1 signaling in primary T cells. Immunol. Rev. 229, 114–125 (2009).

5. Chemnitz, J.M., Parry, R.V., Nichols, K.E., June, C.H. & Riley, J.L. SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation. J. Immunol. 173, 945–954 (2004).

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