Codon-optimized FAM132b gene therapy prevents dietary obesity by blockading adrenergic response and insulin action
Author:
Publisher
Springer Science and Business Media LLC
Subject
Nutrition and Dietetics,Endocrinology, Diabetes and Metabolism,Medicine (miscellaneous)
Link
https://www.nature.com/articles/s41366-022-01189-x.pdf
Reference44 articles.
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2. Qi Z, Ding S. Obesity-associated sympathetic overactivity in children and adolescents: the role of catecholamine resistance in lipid metabolism. J Pediatr Endocrinol Metab. 2016;29:113–25.
3. Seals DR, Bell C. Chronic sympathetic activation: consequence and cause of age-associated obesity? Diabetes. 2004;53:276–84.
4. Marion-Latard F, De Glisezinski I, Crampes F, Berlan M, Galitzky J, Suljkovicova H, et al. A single bout of exercise induces beta-adrenergic desensitization in human adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2001;280:R166–R173.
5. Stich V, De Glisezinski I, Crampes F, Hejnova J, Cottet-Emard JM, Galitzky J, et al. Activation of alpha(2)-adrenergic receptors impairs exercise-induced lipolysis in SCAT of obese subjects. Am J Physiol Regul Integr Comp Physiol. 2000;279:R499–R504.
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