Localized striatal delivery of GDNF as a treatment for Parkinson disease
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nn1175.pdf
Reference49 articles.
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2. Aebischer, P. & Ridet, J. Recombinant proteins for neurodegenerative diseases: the delivery issue. Trends Neurosci. 24, 533–540 (2001).This paper uses a technique involving the fusion of a pore protein to MN to show that promoters associate with nuclear pores in yeast.
3. Gill, S.S. et al. Direct brain infusion of glial cell line-derived neurotrophic factor in Parkinson disease. Nat. Med. 9, 589–595 (2003).
4. Kearns, C.M., Cass, W.A., Smoot, K., Kryscio, R. & Gash, D.M. GDNF protection against 6-OHDA: time dependence and requirement for protein synthesis. J. Neurosci. 17, 7111–7118 (1997).
5. Sullivan, A.M., Opacka-Juffry, J. & Blunt, S.B. Long-term protection of the rat nigrostriatal dopaminergic system by glial cell line-derived neurotrophic factor against 6-hydroxydopamine in vivo. Eur. J. Neurosci. 10, 57–63 (1998).The initial cross-linking study, showing that a range of pore proteins can be crosslinked by formaldehyde to many genes, among which are those induced by galactose.
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