Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson’s disease-Reference-Cited by-同舟云学术

Neuromelanin organelles are specialized autolysosomes that accumulate undegraded proteins and lipids in aging human brain and are likely involved in Parkinson’s disease

Published:2018-06-05 Issue:1 Volume:4 Page:
ISSN:2373-8057
Container-title:npj Parkinson's Disease
language:en
Short-container-title:npj Parkinson's Disease

Author:

Zucca Fabio A.^ORCID,Vanna Renzo^ORCID,Cupaioli Francesca A.,Bellei Chiara,De Palma Antonella,Di Silvestre Dario,Mauri Pierluigi,Grassi Sara,Prinetti Alessandro,Casella Luigi,Sulzer David^ORCID,Zecca Luigi

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Neurology

Link

http://www.nature.com/articles/s41531-018-0050-8.pdf

Reference138 articles.

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2. Sulzer, D. et al. Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease. J. Neurochem. 106, 24–36 (2008).

3. Zecca, L. et al. New melanic pigments in the human brain that accumulate in aging and block environmental toxic metals. Proc. Natl Acad. Sci. USA 105, 17567–17572 (2008).

4. Fedorow, H. et al. Evidence for specific phases in the development of human neuromelanin. Neurobiol. Aging 27, 506–512 (2006).

5. Zecca, L. et al. The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc. Natl Acad. Sci. USA 101, 9843–9848 (2004).

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