Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
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Published:2023-09-12
Issue:1
Volume:9
Page:
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ISSN:2373-8057
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Container-title:npj Parkinson's Disease
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language:en
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Short-container-title:npj Parkinsons Dis.
Author:
Towns Clodagh, Richer MadeleineORCID, Jasaityte SimonaORCID, Stafford Eleanor J.ORCID, Joubert Julie, Antar Tarek, Martinez-Carrasco AlejandroORCID, Makarious Mary B.ORCID, Casey BradfordORCID, Vitale Dan, Levine Kristin, Leonard Hampton, Pantazis Caroline B.ORCID, Screven Laurel A.ORCID, Hernandez Dena G., Wegel Claire E., Solle Justin, Nalls Mike A., Blauwendraat CornelisORCID, Singleton Andrew B.ORCID, Tan Manuela M. X.ORCID, Iwaki Hirotaka, Morris Huw R.ORCID, Gatto Emilia M., Kauffman Marcelo, Khachatryan Samson, Tavadyan Zaruhi, Shepherd Claire E., Hunter Julie, Kumar Kishore, Ellis Melina, Rentería Miguel E., Koks Sulev, Zimprich Alexander, Schumacher-Schuh Artur F., Rieder Carlos, Awad Paula Saffie, Tumas Vitor, Camargos Sarah, Fon Edward A., Monchi Oury, Fon Ted, Galleguillos Benjamin Pizarro, Miranda Marcelo, Bustamante Maria Leonor, Olguin Patricio, Chana Pedro, Tang Beisha, Shang Huifang, Guo Jifeng, Chan Piu, Luo Wei, Arboleda Gonzalo, Orozco Jorge, del Rio Marlene Jimenez, Hernandez Alvaro, Salama Mohamed, Kamel Walaa A., Zewde Yared Z., Brice Alexis, Corvol Jean-Christophe, Westenberger Ana, Illarionova Anastasia, Mollenhauer Brit, Klein Christine, Vollstedt Eva-Juliane, Hopfner Franziska, Höglinger Günter, Madoev Harutyun, Trinh Joanne, Junker Johanna, Lohmann Katja, Lange Lara M., Sharma Manu, Groppa Sergiu, Gasser Thomas, Fang Zih-Hua, Akpalu Albert, Xiromerisiou Georgia, Hadjigorgiou Georgios, Dagklis Ioannis, Tarnanas Ioannis, Stefanis Leonidas, Stamelou Maria, Dadiotis Efthymios, Medina Alex, Chan Germaine Hiu-Fai, Ip Nancy, Cheung Nelson Yuk-Fai, Chan Phillip, Zhou Xiaopu, Kishore Asha, KP Divya, Pal Pramod, Kukkle Prashanth Lingappa, Rajan Roopa, Borgohain Rupam, Salari Mehri, Quattrone Andrea, Valente Enza Maria, Parnetti Lucilla, Avenali Micol, Schirinzi Tommaso, Funayama Manabu, Hattori Nobutaka, Shiraishi Tomotaka, Karimova Altynay, Kaishibayeva Gulnaz, Shambetova Cholpon, Krüger Rejko, Tan Ai Huey, Ahmad-Annuar Azlina, Norlinah Mohamed Ibrahim, Murad Nor Azian Abdul, Azmin Shahrul, Lim Shen-Yang, Mohamed Wael, Tay Yi Wen, Martinez-Ramirez Daniel, Rodriguez-Violante Mayela, Reyes-Pérez Paula, Tserensodnom Bayasgalan, Ojha Rajeev, Anderson Tim J., Pitcher Toni L., Sanyaolu Arinola, Okubadejo Njideka, Ojo Oluwadamilola, Aasly Jan O., Pihlstrøm Lasse, Tan Manuela, Ur-Rehman Shoaib, Cornejo-Olivas Mario, Doquenia Maria Leila, Rosales Raymond, Vinuela Angel, Iakovenko Elena, Mubarak Bashayer Al, Umair Muhammad, Tan Eng-King, Foo Jia Nee, Amod Ferzana, Carr Jonathan, Bardien Soraya, Jeon Beomseok, Kim Yun Joong, Cubo Esther, Alvarez Ignacio, Hoenicka Janet, Beyer Katrin, Periñan Maria Teresa, Pastor Pau, El-Sadig Sarah, Zweier Christiane, Krack Paul, Lin Chin-Hsien, Wu Hsiu-Chuan, Kung Pin-Jui, Wu Ruey-Meei, Wu Yihru, Amouri Rim, Sassi Samia Ben, Başak A. Nazlı, Genc Gencer, Çakmak Özgür Öztop, Ertan Sibel, Noyce Alastair, Schrag Anette, Schapira Anthony, Carroll Camille, Bale Claire, Grosset Donald, Houlden Henry, Hardy John, Mok Kin Ying, Rizig Mie, Wood Nicholas, Williams Nigel, Okunoye Olaitan, Lewis Patrick Alfryn, Kaiyrzhanov Rauan, Weil Rimona, Love Seth, Stott Simon, Jasaitye Simona, Dey Sumit, Obese Vida, Espay Alberto, O’Grady Alyssa, Sobering Andrew K., Siddiqi Bernadette, Fiske Brian, Jonas Cabell, Cruchaga Carlos, Comart Charisse, Wegel Claire, Hall Deborah, Hernandez Dena, Shiamim Ejaz, Riley Ekemini, Faghri Faraz, Serrano Geidy E., Chen Honglei, Mata Ignacio F., Sarmiento Ignacio Juan Keller, Williamson Jared, Kim Jonggeol Jeff, Jankovic Joseph, Shulman Joshua, Solle Justin C., Murphy Kaileigh, Nuytemans Karen, Kieburtz Karl, Markopoulou Katerina, Marek Kenneth, Levine Kristin S., Chahine Lana M., Ibanez Laura, Screven Laurel, Ruffrage Lauren, Shulman Lisa, Marsili Luca, Kuhl Maggie, Dean Marissa, Koretsky Mathew, Puckelwartz Megan J., Inca-Martinez Miguel, Louie Naomi, Mencacci Niccolò Emanuele, Albin Roger, Alcalay Roy, Walker Ruth, Bandres-Ciga Sara, Chowdhury Sohini, Dumanis Sonya, Lubbe Steven, Xie Tao, Foroud Tatiana, Beach Thomas, Sherer Todd, Song Yeajin, Nguyen Duan, Nguyen Toan, Atadzhanov Masharip,
Abstract
AbstractThe Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.
Funder
Michael J. Fox Foundation for Parkinson’s Research U.S. Department of Health & Human Services | NIH | National Institute on Aging Aligning Science Across Parkinson’s Initiative (ASAP). Above grants are awarded to authors A.B. Singleton and C. Blauwendraat. Aligning Science Across Parkinson’s Initiative (ASAP).
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology (clinical),Neurology
Reference34 articles.
1. Nalls, M. A. et al. Identification of novel risk loci, causal insights, and heritable risk for Parkinson’s disease: a meta-analysis of genome-wide association studies. Lancet Neurol. 18, 1091–1102 (2019). 2. Iwaki, H. et al. Genetic risk of Parkinson disease and progression: an analysis of 13 longitudinal cohorts. Neurol. Genet. 5, 1–14 (2019). 3. Latourelle, J. C. et al. Large-scale identification of clinical and genetic predictors of Parkinson’s disease motor progression in newly-diagnosed patients: a longitudinal cohort study and validation. Lancet Neurol. 16, 908–916 (2017). 4. Tan, M. M. X. et al. Genome-wide association studies of cognitive and motor progression in Parkinson’s disease. Mov. Disord. 36, 424–433 (2021). 5. Heinzel, S., Lerche, S., Maetzler, W. & Berg, D. Global, yet incomplete overview of cohort studies in Parkinson’s disease. J. Parkinsons. Dis. 7, 423–432 (2017).
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