Identifying potential causal effects of Parkinson’s disease: A polygenic risk score-based phenome-wide association and mendelian randomization study in UK Biobank-Reference-Cited by-同舟云学术

Identifying potential causal effects of Parkinson’s disease: A polygenic risk score-based phenome-wide association and mendelian randomization study in UK Biobank

Published:2024-09-06 Issue:1 Volume:10 Page:
ISSN:2373-8057
Container-title:npj Parkinson's Disease
language:en
Short-container-title:npj Parkinsons Dis.

Author:

Shi Changhe^ORCID,Ma Dongrui,Li Mengjie,Wang Zhiyun,Hao Chenwei,Liang Yuanyuan,Feng Yanmei,Hu Zhengwei,Hao Xiaoyan,Guo Mengnan,Li Shuangjie,Zuo Chunyan,Sun Yuemeng,Tang Mibo,Mao Chengyuan,Zhang Chan,Xu Yuming,Sun Shilei

Funder

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41531-024-00780-5.pdf

Reference43 articles.

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2. Ascherio, A. & Schwarzschild, M. A. The epidemiology of Parkinson’s disease: risk factors and prevention. Lancet Neurol. 15, 1257–1272, https://doi.org/10.1016/s1474-4422(16)30230-7 (2016).

3. Bloem, B. R., Okun, M. S. & Klein, C. Parkinson’s disease. Lancet 397, 2284–2303, https://doi.org/10.1016/s0140-6736(21)00218-x (2021).

4. Nalls, M. A. et al. Identification of novel risk loci, causal insights, and heritable risk for Parkinson’s disease: a meta-analysis of genome-wide association studies. Lancet Neurol. 18, 1091–1102, https://doi.org/10.1016/s1474-4422(19)30320-5 (2019).

5. Nong, W., Mo, G. & Luo, C. Exploring the bidirectional causal link between household income status and genetic susceptibility to neurological diseases: findings from a Mendelian randomization study. Front. Public Health 11, 1202747, https://doi.org/10.3389/fpubh.2023.1202747 (2023).