IL-2 prevents deletion of developing T-regulatory cells in the thymus
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/cdd201738.pdf
Reference39 articles.
1. Baldwin KK, Trenchak BP, Altman JD, Davis MM . Negative selection of T cells occurs throughout thymic development. J Immunol 1999; 163: 689–698.
2. Douek DC, Corley KT, Zal T, Mellor A, Dyson PJ, Altmann DM . Negative selection by endogenous antigen and superantigen occurs at multiple thymic sites. Int Immunol 1996; 8: 1413–1420.
3. McCaughtry TM, Baldwin TA, Wilken MS, Hogquist KA . Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla. J Exp Med 2008; 205: 2575–2584.
4. Cowan JE, Parnell SM, Nakamura K, Caamano JH, Lane PJ, Jenkinson EJ et al. The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development. J Exp Med 2013; 210: 675–681.
5. Hu DY, Yap JY, Wirasinha RC, Howard DR, Goodnow CC, Daley SR . A timeline demarcating two waves of clonal deletion and Foxp3 upregulation during thymocyte development. Immunol Cell Biol 2016; 94: 357–366.
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