Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis-Reference-Cited by-同舟云学术

Targeting ACE2-BRD4 crosstalk in colorectal cancer and the deregulation of DNA repair and apoptosis

Published:2023-02-18 Issue:1 Volume:7 Page:
ISSN:2397-768X
Container-title:npj Precision Oncology
language:en
Short-container-title:npj Precis. Onc.

Author:

Zhang Shilan,Kapoor Sabeeta,Tripathi Chakrapani,Perez Jorge Tovar,Mohan Nivedhitha,Dashwood Wan Mohaiza,Zhang Ke,Rajendran Praveen^ORCID,Dashwood Roderick^ORCID

Abstract

AbstractACE2 overexpression in colorectal cancer patients might increase susceptibility to SARS-CoV-2 infection. We report that knockdown, forced overexpression, and pharmacologic inhibition in human colon cancer cells targeted ACE2-BRD4 crosstalk to mediate marked changes in DNA damage/repair and apoptosis. In colorectal cancer patients for whom high ACE2 plus high BRD4 expression is predictive of poor survival, pan-BET inhibition would need to consider proviral/antiviral actions of different BET proteins during SARS-CoV-2 infection.

Funder

Division of Cancer Prevention, National Cancer Institute

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology

Link

https://www.nature.com/articles/s41698-023-00361-4.pdf

Reference21 articles.

1. Liu, C. et al. High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients. npj Precision Oncol. 5, 1 (2021).

2. Redd, W. D. et al. Prevalence and characteristics of gastrointestinal symptoms in patients with SARS-Cov-2 infection in the United States: a multicenter cohort study. Gastroenterology 159, 765–767.e2 (2020).

3. Wu, Y. et al. Prolonged presence of SARS-CoV-2 viral RNA in faecal samples. Lancet Gastroenterol. Hepatol. 5, 434–435 (2020).

4. Fujisawa, T. & Filippakopoulos, P. Functions of bromodomain-containing proteins and their roles in homoeostasis and cancer. Nat. Rev. Mol. Cell Biol. 18, 246–262 (2017).

5. Mazur, P. K. et al. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat. Med. 21, 1163–1171 (2015).

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