A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases-Reference-Cited by-同舟云学术

A method to decipher pleiotropy by detecting underlying heterogeneity driven by hidden subgroups applied to autoimmune and neuropsychiatric diseases

Published:2016-05-16 Issue:7 Volume:48 Page:803-810
ISSN:1061-4036
Container-title:Nature Genetics
language:en
Short-container-title:Nat Genet

Author:

Han Buhm, ,Pouget Jennie G,Slowikowski Kamil,Stahl Eli,Lee Cue Hyunkyu,Diogo Dorothee,Hu Xinli,Park Yu Rang,Kim Eunji,Gregersen Peter K,Dahlqvist Solbritt Rantapää,Worthington Jane,Martin Javier,Eyre Steve,Klareskog Lars,Huizinga Tom,Chen Wei-Min,Onengut-Gumuscu Suna,Rich Stephen S,Wray Naomi R,Raychaudhuri Soumya

Publisher

Springer Science and Business Media LLC

Subject

Genetics

Link

http://www.nature.com/articles/ng.3572.pdf

Reference45 articles.

1. Sivakumaran, S. et al. Abundant pleiotropy in human complex diseases and traits. Am. J. Hum. Genet. 89, 607–618 (2011).

2. Cotsapas, C. et al. Pervasive sharing of genetic effects in autoimmune disease. PLoS Genet. 7, e1002254 (2011).

3. Cross-Disorder Group of the Psychiatric Genomics Consortium. Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. Lancet 381, 1371–1379 (2013).

4. Fortune, M.D. et al. Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls. Nat. Genet. 47, 839–846 (2015).

5. Lee, S.H., Yang, J., Goddard, M.E., Visscher, P.M. & Wray, N.R. Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism–derived genomic relationships and restricted maximum likelihood. Bioinformatics 28, 2540–2542 (2012).

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