Integrative biology of T cell activation
Author:
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy
Link
http://www.nature.com/articles/ni.2959.pdf
Reference104 articles.
1. Huang, J. et al. A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4+ T cells. Immunity 39, 846–857 (2013).Two key papers (refs. 1 and 3) showing that a single peptide-MHC suffices to trigger T cell activation.
2. Manz, B.N., Jackson, B.L., Petit, R.S., Dustin, M.L. & Groves, J. T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters. Proc. Natl. Acad. Sci. USA 108, 9089–9094 (2011).
3. O'Donoghue, G.P., Pielak, R.M., Smoligovets, A.A., Lin, J.J. & Groves, J.T. Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells. eLife 2, e00778 (2013).
4. Houtman, J.C., Houghtling, R.A., Barda-Saad, M., Toda, Y. & Samelson, L.E. Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways. J. Immunol. 175, 2449–2458 (2005).
5. Huse, M. et al. Spatial and temporal dynamics of T cell receptor signaling with a photoactivatable agonist. Immunity 27, 76–88 (2007).Two key papers (refs. 5 and 6) showing the high speed at which TCR signaling proceeds.
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