A Semi-Mechanistic Metabolism Model of CYP3A Substrates in Pregnancy: Predicting Changes in Midazolam and Nifedipine Pharmacokinetics

Author:

Quinney SK11,Mohamed AN2,Hebert MF34,Haas DM11,Clark S5,Umans JG67,Caritis SN8,Li L9,

Affiliation:

1. Department of Obstetrics and Gynecology and Department of Medicine Division of Clinical Pharmacology; Indiana University School of Medicine; Indianapolis Indiana USA

2. Department of Pharmaceutical Practice; Purdue University College of Pharmacy; Indianapolis Indiana USA

3. Department of Pharmacy; University of Washington, Seattle; Washington USA

4. Department of Obstetrics and Gynecology; University of Washington, Seattle; Washington USA

5. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology; University of Texas Medical Branch; Galveston Texas USA

6. Department of Medicine; Georgetown University, Washington; District of Columbia USA

7. Department of Biostatistics; Epidemiology, Outcomes, and Data Management, MedStar Research Institute; Hyattsville Maryland USA

8. Divisions of Reproductive Infectious Diseases and Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Magee-Women's Hospital; University of Pittsburgh Medical Center; Pittsburgh Pennsylvania USA

9. Department of Medical and Molecular Genetics, Center for Computational Biology and Bioinformatics; Indiana Institute of Personalized Medicine Indiana University School of Medicine; Indianapolis Indiana USA

Publisher

Wiley

Subject

Pharmacology (medical),Modeling and Simulation

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