High frequency of pathogenic germline variants within homologous recombination repair in patients with advanced cancer

Author:

Bertelsen Birgitte,Tuxen Ida Viller,Yde Christina Westmose,Gabrielaite MigleORCID,Torp Mathias Husted,Kinalis Savvas,Oestrup Olga,Rohrberg Kristoffer,Spangaard Iben,Santoni-Rugiu Eric,Wadt KarinORCID,Mau-Sorensen Morten,Lassen Ulrik,Nielsen Finn Cilius

Funder

Region Hovedstaden

Publisher

Springer Science and Business Media LLC

Subject

Genetics (clinical),Genetics,Molecular Biology

Reference68 articles.

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2. Le Tourneau, C. et al. Randomised proof-of-concept phase II trial comparing targeted therapy based on tumour molecular profiling vs conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial. Br. J. Cancer 111, 17–24 (2014).

3. Massard, C. et al. High-throughput genomics and clinical outcome in hard-to-treat advanced cancers: results of the MOSCATO 01 Trial. Cancer Discov. 7, 586–595 (2017).

4. Tsimberidou, A. M. et al. Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative. Clin. Cancer Res. 18, 6373–6383 (2012).

5. Tuxen, I. V. et al. Copenhagen Prospective Personalized Oncology (CoPPO) – Clinical utility of using molecular profiling to select patients to phase 1 trials. Clin. Cancer Res. 25, 1239–1247 (2019).

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