Photovoltaic neurointerface based on aluminum antimonide nanocrystals

Author:

Han MertcanORCID,Bahmani Jalali HoumanORCID,Yildiz ErdostORCID,Qureshi Mohammad HaroonORCID,Şahin Afsun,Nizamoglu SedatORCID

Abstract

AbstractLight activated modulation of neural activity is an emerging field for the basic investigation of neural systems and development of new therapeutic methods such as artificial retina. Colloidal inorganic nanocrystals have great potential for neural interfaces due to their adjustable optoelectronic properties via high-level structural, compositional, and size control. However, toxic heavy metal content (e.g., cadmium, mercury), electrochemical coupling to the cells and low photon-to-current efficiency limit their effective use. Here, we introduce the use of aluminum antimonide (AlSb) nanocrystals as the cell interfacing layer for capacitive neural stimulation in the blue spectrum. We demonstrate successful photostimulation of primary hippocampal neurons below ocular safety limits. In addition, our device shows high biocompatibility in vitro and passive accelerated ageing tests indicate a functional lifetime over 3 years showing their feasible use for chronic implants. We demonstrate that nanocrystal biointerfaces hold high promise for future bioelectronics and protheses.

Publisher

Springer Science and Business Media LLC

Subject

General Medicine

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