Short-term dietary changes can result in mucosal and systemic immune depression

Author:

Siracusa FrancescoORCID,Schaltenberg Nicola,Kumar Yogesh,Lesker Till R.,Steglich Babett,Liwinski Timur,Cortesi FilippoORCID,Frommann Laura,Diercks Björn-PhillipORCID,Bönisch Friedericke,Fischer Alexander W.,Scognamiglio PasqualeORCID,Pauly Mira J.,Casar Christian,Cohen Yotam,Pelczar Penelope,Agalioti Theodora,Delfs Flemming,Worthmann Anna,Wahib Ramez,Jagemann Bettina,Mittrücker Hans-WilliORCID,Kretz Oliver,Guse Andreas H.ORCID,Izbicki Jakob R.,Lassen Kara G.,Strowig TillORCID,Schweizer Michaela,Villablanca Eduardo J.ORCID,Elinav EranORCID,Huber SamuelORCID,Heeren Joerg,Gagliani NicolaORCID

Abstract

AbstractOmnivorous animals, including mice and humans, tend to prefer energy-dense nutrients rich in fat over plant-based diets, especially for short periods of time, but the health consequences of this short-term consumption of energy-dense nutrients are unclear. Here, we show that short-term reiterative switching to ‘feast diets’, mimicking our social eating behavior, breaches the potential buffering effect of the intestinal microbiota and reorganizes the immunological architecture of mucosa-associated lymphoid tissues. The first dietary switch was sufficient to induce transient mucosal immune depression and suppress systemic immunity, leading to higher susceptibility to Salmonella enterica serovar Typhimurium and Listeria monocytogenes infections. The ability to respond to antigenic challenges with a model antigen was also impaired. These observations could be explained by a reduction of CD4+ T cell metabolic fitness and cytokine production due to impaired mTOR activity in response to reduced microbial provision of fiber metabolites. Reintroducing dietary fiber rewired T cell metabolism and restored mucosal and systemic CD4+ T cell functions and immunity. Finally, dietary intervention with human volunteers confirmed the effect of short-term dietary switches on human CD4+ T cell functionality. Therefore, short-term nutritional changes cause a transient depression of mucosal and systemic immunity, creating a window of opportunity for pathogenic infection.

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

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