Modulation of CD19 surface expression in B cell acute lymphoblastic leukemia

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Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Reference4 articles.

1. Shah, N. N. & Fry, T. J. Mechanisms of resistance to CAR T cell therapy. Nat. Rev. Clin. Oncol. 16, 372–385 (2019). A review article discussing lessons learned from the clinical use of CD19 CAR-T therapy, including CAR-T treatment mechanisms.

2. Sotillo, E. et al. Convergence of acquired mutations and alternative splicing of CD19 enables resistance to CART-19 immunotherapy. Cancer Discov. 5, 1282–1295 (2015). This seminal study describes CD19 genomic locus mutations and alternative splicing events that lead to CD19 CAR-T resistance.

3. Zhao, Y. et al. Tumor-intrinsic and -extrinsic determinants of response to blinatumomab in adults with B-ALL. Blood 137, 471–484 (2021). Extensive characterization of blinatumomab therapy in patients with primary B-ALL, including extensive kinetic analysis of treatment responses and relapse.

4. Kozmik, Z., Wang, S., Dorfler, P., Adams, B. & Busslinger, M. The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP. Mol. Cell Biol. 12, 2662–2672 (1992). Original study highlighting the role of PAX5 (also known as BSAP) in activating CD19 mRNA expression via promoter binding.

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