High-dimensional analysis of 16 SARS-CoV-2 vaccine combinations reveals lymphocyte signatures correlating with immunogenicity
-
Published:2023-04-24
Issue:6
Volume:24
Page:941-954
-
ISSN:1529-2908
-
Container-title:Nature Immunology
-
language:en
-
Short-container-title:Nat Immunol
Author:
Nuñez Nicolás GonzaloORCID, Schmid JonasORCID, Power Laura, Alberti Chiara, Krishnarajah SinduyaORCID, Kreutmair StefanieORCID, Unger Susanne, Blanco Sebastián, Konigheim Brenda, Marín ConstanzaORCID, Onofrio LuisinaORCID, Kienzler Jenny ChristineORCID, Costa-Pereira Sara, Ingelfinger Florian, Cerbán Fabio, Chiapello Laura, Montes Carolina, Motrán Cristina, Dutto Jeremías, Almada Laura, Boffelli Lucía, Spinsanti Lorena, Díaz Adrián, Rivarola María Elisa, Bioq Javier Aguilar, Beranek Mauricio, Pasinovich Marina E., Castelli Juan M., Vizzotti Carla, Schaefer MaximilianORCID, Villar-Vesga Juan, Mundt Sarah, Merten Carla Helena, Sethi Aakriti, Wertheimer Tobias, Lutz Mirjam, Vanoaica Danusia, Sotomayor Claudia, Gruppi Adriana, Münz ChristianORCID, Cardozo Diego, Barbás Gabriela, Lopez Laura, Carreño Paula, Castro Gonzalo, Raboy Elias, Gallego Sandra, Morón GabrielORCID, Cervi Laura, Acosta Rodriguez Eva V.ORCID, Maletto Belkys A., Maccioni MarianaORCID, Becher BurkhardORCID, ,
Abstract
AbstractThe range of vaccines developed against severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) provides a unique opportunity to study immunization across different platforms. In a single-center cohort, we analyzed the humoral and cellular immune compartments following five coronavirus disease 2019 (COVID-19) vaccines spanning three technologies (adenoviral, mRNA and inactivated virus) administered in 16 combinations. For adenoviral and inactivated-virus vaccines, heterologous combinations were generally more immunogenic compared to homologous regimens. The mRNA vaccine as the second dose resulted in the strongest antibody response and induced the highest frequency of spike-binding memory B cells irrespective of the priming vaccine. Priming with the inactivated-virus vaccine increased the SARS-CoV-2-specific T cell response, whereas boosting did not. Distinct immune signatures were elicited by the different vaccine combinations, demonstrating that the immune response is shaped by the type of vaccines applied and the order in which they are delivered. These data provide a framework for improving future vaccine strategies against pathogens and cancer.
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy
Reference62 articles.
1. Sadarangani, M., Marchant, A. & Kollmann, T. R. Immunological mechanisms of vaccine-induced protection against COVID-19 in humans. Nat. Rev. Immunol. 21, 475–484 (2021). 2. Pozzetto, B. et al. Immunogenicity and efficacy of heterologous ChAdOx1–BNT162b2 vaccination. Nature 600, 701–706 (2021). 3. Barros-Martins, J. et al. Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination. Nat. Med. 27, 1525–1529 (2021). 4. Pereson, M. J. et al. Heterologous gam-covid-vac (sputnik V)/mRNA-1273 (Moderna) vaccination induces a stronger humoral response than homologous sputnik V in a real-world data analysis. Clin. Microbiol. Infect. 1273, 382–1388 (2022). 5. Hillus, D. et al. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study. Lancet Respir. Med. 9, 1255–1265 (2021).
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
|
|