Reversing T cell immunity reveals the basis for T cell lineage fate determination
Author:
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy
Link
https://www.nature.com/articles/s41590-022-01195-1.pdf
Reference5 articles.
1. Taniuchi, I. CD4 Helper and CD8 Cytotoxic T Cell Differentiation. Annu. Rev. Immunol. 36, 579–601 (2018). This review summarizes the transcription factor network that regulates T cell lineage fate.
2. Itano, A. et al. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells. J. Exp. Med. 183, 731–741 (1996). This study proposes that coreceptor signaling strength dictates the helper versus cytotoxic lineage fate.
3. Karimi, M. M. et al. The order and logic of CD4 versus CD8 lineage choice and differentiation in mouse thymus. Nat. Commun. 12, 99 (2021). This study uses single-cell RNA sequencing of thymocytes to conclude that signaling strength is the basis of T cell lineage determination.
4. Singer, A., Adoro, S. & Park, J. H. Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice. Nat. Rev. Immunol. 8, 788–801 (2008). This review discusses different perspectives of lineage fate determination in the thymus.
5. Brugnera, E. et al. Coreceptor reversal in the thymus: signaled CD4+8+ thymocytes initially terminate CD8 transcription even when differentiating into CD8+ T cells. Immunity 13, 59–71 (2000). This study proposes the kinetic signaling model.
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