Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease-Reference-Cited by-同舟云学术

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Published:2024-04 Issue:4 Volume:25 Page:607-621
ISSN:1529-2908
Container-title:Nature Immunology
language:en
Short-container-title:Nat Immunol

Author:

Liew Felicity,Efstathiou Claudia^ORCID,Fontanella Sara,Richardson Matthew,Saunders Ruth,Swieboda Dawid,Sidhu Jasmin K.,Ascough Stephanie,Moore Shona C.^ORCID,Mohamed Noura,Nunag Jose^ORCID,King Clara,Leavy Olivia C.,Elneima Omer,McAuley Hamish J. C.,Shikotra Aarti,Singapuri Amisha^ORCID,Sereno Marco^ORCID,Harris Victoria C.,Houchen-Wolloff Linzy^ORCID,Greening Neil J.^ORCID,Lone Nazir I.^ORCID,Thorpe Matthew,Thompson A. A. Roger^ORCID,Rowland-Jones Sarah L.,Docherty Annemarie B.^ORCID,Chalmers James D.,Ho Ling-Pei^ORCID,Horsley Alexander^ORCID,Raman Betty,Poinasamy Krisnah,Marks Michael,Kon Onn Min,Howard Luke S.^ORCID,Wootton Daniel G.,Quint Jennifer K.,de Silva Thushan I.^ORCID,Ho Antonia,Chiu Christopher^ORCID,Harrison Ewen M.^ORCID,Greenhalf William,Baillie J. Kenneth^ORCID,Semple Malcolm G.^ORCID,Turtle Lance,Evans Rachael A.^ORCID,Wain Louise V.,Brightling Christopher,Thwaites Ryan S.^ORCID,Openshaw Peter J. M.^ORCID, ,Abel Kathryn,Adamali H.,Adeloye Davies,Adeyemi Oluwaseun,Adrego Rita,Jimenez Laura Aguilar,Ahmad Shanaz,Haider N. Ahmad,Ahmed Rubina,Ahwireng Nyarko,Ainsworth Mark,Alamoudi Asma,Ali Mariam,Aljaroof M.,Allan Louise,Allen Richard,Allerton Lisa,Allsop Lynne,Allt Ann Marie,Almeida Paula,Al-Sheklly Bashar,Altmann Danny,Corral Maria Alvarez,Amoils Shannon,Anderson David,Antoniades Charalambos,Arbane Gill,Arias Ava Maria,Armour Cherie,Armstrong Lisa,Armstrong Natalie,Arnold David,Arnold H.,Ashish A.,Ashworth Andrew,Ashworth M.,Aslani Shahab,Assefa-Kebede Hosanna,Atkin Paul,Atkin Catherine,Aul Raminder,Aung Hnin,Austin Liam,Avram Cristina,Avramidis Nikos,Ayoub A.,Babores Marta,Baggott Rhiannon,Bagshaw J.,Baguley David,Bailey Elisabeth,Baillie J. Kenneth,Bain Steve,Bakali Majda,Bakau M.,Baldry E.,Baldwin Molly,Baldwin David,Ballard Clive,Banerjee Amita,Bang Dongchun,Barker R. E.,Barman Laura,Barran Perdita,Barratt Shaney,Barrett Fiona,Basire Donna,Basu Neil,Bates Michelle,Bates A.,Batterham R.,Baxendale Helen,Baxter Gabrielle,Bayes Hannah,Beadsworth M.,Beckett Paul,Beggs M.,Begum M.,Beirne Paul,Bell Murdina,Bell Robert,Bennett Kaytie,Beranova Eva,Bermperi Areti,Berridge Anthony,Berry Colin,Betts Sarah,Bevan Emily,Bhui Kamaldeep,Bingham Michelle,Birchall K.,Bishop Lettie,Bisnauthsing Karen,Blaikely John,Bloss Angela,Bolger Annette,Bolton Charlotte,Bonnington J.,Botkai A.,Bourne Charlotte,Bourne Michelle,Bramham Kate,Brear Lucy,Breen G.,Breeze Jonathon,Breeze Katie,Briggs Andrew,Bright E.,Brill Simon,Brindle K.,Broad Lauren,Broadley Andrew,Brookes Claire,Broome Mattew,Brown Vanessa,Brown M.,Brown Jo,Brown J.,Brown Ammani,Brown Angela,Brown M.,Brown Jeremy,Brugha Terry,Brunskill Nigel,Buch M.,Buckley Phil,Bularga Anda,Bullmore Ed,Bunker Jenny,Burden L.,Burdett Tracy,Burn David,Burns G.,Burns A.,Busby John,Butcher Robyn,Butt Al-Tahoor,Byrne S.,Cairns P.,Calder P. 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W.,Twagira Mary,Vallotton Nick,van Tonder Libby,Vancheeswaran Rama,Vincent Rachel,Vincent-Smith Lisa,Visuvanathan Shico,Vuylsteke Alan,Waddy Sam,Wake Rachel,Walden Andrew,Welters Ingeborg,Wham Murray,Whitehouse Tony,Whittaker Paul,Whittington Ashley,Wijesinghe Meme,Wilcock Eve,Williams Martin,Wilson Lawrence,Winchester Stephen,Wiselka Martin,Wolverson Adam,Wootton Daniel G.,Workman Andrew,Wrobel Nicola,Yates Bryan,Young Peter,Zambon Maria,Zhang J. Eunice

Abstract

AbstractOne in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged symptoms termed long coronavirus disease (COVID), yet disease phenotypes and mechanisms are poorly understood1. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain–gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials.

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41590-024-01778-0.pdf

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