Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease
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Published:2021-12-22
Issue:1
Volume:23
Page:75-85
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ISSN:1529-2908
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Container-title:Nature Immunology
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language:en
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Short-container-title:Nat Immunol
Author:
Kubo SatoshiORCID, Fritz Jill M., Raquer-McKay Hayley M., Kataria Rhea, Vujkovic-Cvijin IvanORCID, Al-Shaibi AhmadORCID, Yao Yikun, Zheng Lixin, Zou Juan, Waldman Alex D.ORCID, Jing Xinyi, Farley Taylor K., Park Ann Y.ORCID, Oler Andrew J.ORCID, Charles Adrian K.ORCID, Makhlouf Melanie, AbouMoussa Eman H., Hasnah Reem, Saraiva Luis R.ORCID, Ganesan Sundar, Al-Subaiey Abdulrahman Ahmed, Matthews Helen, Flano Emilio, Lee Hyun Hee, Freeman Alexandra F., Sefer Asena Pınar, Sayar Ersin, Çakır Erkan, Karakoc-Aydiner Elif, Baris SafaORCID, Belkaid YasmineORCID, Ozen AhmetORCID, Lo BerniceORCID, Lenardo Michael J.ORCID
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy
Reference60 articles.
1. Williams, R. A., Mamotte, C. D. & Burnett, J. R. Phenylketonuria: an inborn error of phenylalanine metabolism. Clin. Biochem. Rev. 29, 31–41 (2008). 2. Freeman, M. The rhomboid-like superfamily: molecular mechanisms and biological roles. Annu. Rev. Cell Dev. Biol. 30, 235–254 (2014). 3. Lambrecht, B. N., Vanderkerken, M. & Hammad, H. The emerging role of ADAM metalloproteinases in immunity. Nat. Rev. Immunol. 18, 745–758 (2018). 4. Dulloo, I., Muliyil, S. & Freeman, M. The molecular, cellular and pathophysiological roles of iRhom pseudoproteases. Open Biol. 9, 190003 (2019). 5. Adrain, C., Zettl, M., Christova, Y., Taylor, N. & Freeman, M. Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science 335, 225–228 (2012).
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