The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING

The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway

Published:2021-03-25 Issue:4 Volume:22 Page:485-496
ISSN:1529-2908
Container-title:Nature Immunology
language:en
Short-container-title:Nat Immunol

Author:

Takahashi Mariko^ORCID,Lio Chan-Wang J.^ORCID,Campeau Anaamika,Steger Martin,Ay Ferhat^ORCID,Mann Matthias^ORCID,Gonzalez David J.,Jain Mohit,Sharma Sonia^ORCID

Funder

U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research

U.S. Department of Health & Human Services | NIH | National Cancer Institute

Cancer Research Institute

CRI postdoctoral fellowship

U.S. Department of Health & Human Services | NIH | NIH Office of the Director

U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences

U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Link

http://www.nature.com/articles/s41590-021-00896-3.pdf

Reference60 articles.

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3. Kwon, J. & Bakhoum, S. F. The cytosolic DNA-sensing cGAS–STING pathway in cancer. Cancer Discov. 10, 26–39 (2020).

4. Chen, Q., Sun, L. & Chen, Z. J. Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing. Nat. Immunol. 17, 1142–1149 (2016).

5. Corrales, L., McWhirter, S. M., Dubensky, T. W. Jr. & Gajewski, T. F. The host STING pathway at the interface of cancer and immunity. J. Clin. Investig. 126, 2404–2411 (2016).

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