Improvement of the reverse tetracycline transactivator by single amino acid substitutions that reduce leaky target gene expression to undetectable levels-Reference-Cited by-同舟云学术

Improvement of the reverse tetracycline transactivator by single amino acid substitutions that reduce leaky target gene expression to undetectable levels

Published:2016-06-21 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Roney Ian J.,Rudner Adam D.,Couture Jean-François,Kærn Mads

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep27697.pdf

Reference31 articles.

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2. Wishart, J. A., Hayes, A., Wardleworth, L., Zhang, N. & Oliver, S. G. Doxycycline, the drug used to control thetet-regulatable promoter system, has no effect on global gene expression inSaccharomyces cerevisiae. Yeast 22, 565–569 (2005).

3. Bell, G. An activator/repressor dual system allows tight tetracycline-regulated gene expression in budding yeast. Nucleic Acids Research 26, 942–947 (1998).

4. Hoyng, S. A. et al. Developing a potentially immunologically inert tetracycline-regulatable viral vector for gene therapy in the peripheral nerve. Gene Therapy 21, 549–557 (2014).

5. Agha-Mohammadi, S. et al. Second-generation tetracycline-regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness. The Journal of Gene Medicine 6, 817–828 (2004).

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