Immunomodulation to enhance gene therapy
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Biochemistry, Genetics and Molecular Biology,General Medicine
Link
http://www.nature.com/articles/nm0995-887.pdf
Reference16 articles.
1. Yang, Y., Trinchieri, G. & Wilson, J.M. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nature Med. 1, 890–893 (1995).
2. van Ginkel, F.W. et al. Intratracheal gene delivery with adenoviral vector induces elevated systemic IgG and mucosal IgA antibodies to adenovirus and β-galactosidase. Hum. Gene Ther. 6, 895–903 (1995).
3. Yang, Y. et al. Inactivation of E2a in recombinant adenoviruses limits cellular immunity and improves the prospect for gene therapy of cystic fibrosis. Nature Genet. 7, 362–369 (1994).
4. Yang, Y., Li, Q., Ertl, H.C.J. & Wilson, J.M. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004–2015 (1995).
5. Simon, R.H. et al. Adenovirus-mediated transfer of the CFTR gene to lung of non-human primates: Toxicity study. Hum. Gene Ther. 4, 771–780 (1993).
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