Author:
Kondo Hiroaki,Sakuyama Tomari Hiroe,Yamakawa Shoko,Kitagawa Manabu,Yamada Minami,Itou Seiki,Yamamoto Tetsuro,Uehara Yoshio
Abstract
AbstractThe present study aimed to investigate the effects of the combination of Marukome Nenrin miso, which has natriuretic effects, and Marukome MK-34-1 miso, which has potent angiotensin converting enzyme inhibitory effects, on blood pressure (BP) in humans. A total of 40 subjects aged 40–69 years with high-normal BP or stage I hypertension were randomly assigned to two groups: 1) the miso group (32 g 2:1 w/w Nenrin and MK-34-1 with 3.8 g salt/day) or 2) the control soy food group (14.4 g soy food with 0.2 g salt/day). The levels of major nutrients were equal in the miso and control food servings, except for the fiber and Na levels, which were higher in the miso food serving. Daytime and nighttime BP were measured with an automated BP monitor. Compared with the soy food intake, miso intake for 8 weeks did not affect daytime clinical BP but significantly decreased nighttime BP without affecting pulse rate (PR). Moreover, miso shifted the nighttime BP profile to lower levels than those at baseline. Soy food intake did not change the nighttime BP profile after 8 weeks. Miso intake also tended to reduce nighttime BP in a subgroup with stage 1 hypertension compared with the results of the soy food group participants and shifted the nighttime BP profile toward lower levels than those recorded at baseline. Miso intake did not influence lipid or glucose metabolism. In conclusion, this is the first report showing that miso reduces nighttime BP in humans. Miso may do so by shrinking the fluid spaces in the body and/or deactivating the adrenergic nervous system.
Publisher
Springer Science and Business Media LLC
Subject
Cardiology and Cardiovascular Medicine,Physiology,Internal Medicine
Reference15 articles.
1. Mente A, O’Donnell MJ, Rangarajan S, McQueen MJ, Poirier P, Wielgosz A, et al. PURE Investigators. Association of Urinary Sodium and Potassium Excretion with blood pressure. N Engl J Med. 2014;371:601–11.
2. Liu H, Gao X, Zhou L, Wu Y, Li Y, Mai J, et al. Urinary sodium excretion and risk of cardiovascular disease in the Chinese population: a prospective study. Hypertens Res. 2018;41:849–55.
3. Sakuyama H, Tachizaki N, Nanmo A, Yamada K, Uehara Y. The influence of intake of daily Miso soup on blood pressure in humans-The results of 5-year observational study-. J Jpn Soc Med Use Func Foods. 2017;10:361–8.
4. Kitagawa M, Itoh K, Yamada M, Koike S, Yamamoto T, Uehara Y. Long term intake of Miso soup unaffected blood pressure in subjects with normal or stage I hypertension-Double blind comparative intervention trial-. Jpn Pharm Ther. 2016;44:1601–12.
5. Yoshinaga M, Toda N, Tamura Y, Terakado S, Ueno M, Otsuka K, et al. Japanese traditional miso soup attenuates salt-induced hypertension and its organ damage in Dahl salt-sensitive rats. Nutrition. 2012;28:924–31.
Cited by
10 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献