Abstract
AbstractHyperammonaemia in children can lead to grave consequences in the form of cerebral oedema, severe neurological impairment and even death. In infants and children, common causes of hyperammonaemia include urea cycle disorders or organic acidaemias. Few studies have assessed the role of extracorporeal therapies in the management of hyperammonaemia in neonates and children. Moreover, consensus guidelines are lacking for the use of non-kidney replacement therapy (NKRT) and kidney replacement therapies (KRTs, including peritoneal dialysis, continuous KRT, haemodialysis and hybrid therapy) to manage hyperammonaemia in neonates and children. Prompt treatment with KRT and/or NKRT, the choice of which depends on the ammonia concentrations and presenting symptoms of the patient, is crucial. This expert Consensus Statement presents recommendations for the management of hyperammonaemia requiring KRT in paediatric populations. Additional studies are required to strengthen these recommendations.
Publisher
Springer Science and Business Media LLC
Reference69 articles.
1. Auron, A. & Brophy, P. D. Hyperammonemia in review: pathophysiology, diagnosis, and treatment. Pediatr. Nephrol. 27, 207–222 (2012).
2. Gupta, S., Fenves, A. Z. & Hootkins, R. The role of RRT in hyperammonemic patients. Clin. J. Am. Soc. Nephrol. 11, 1872–1878 (2016).
3. Upadhyay, R., Bleck, T. P. & Busl, K. M. Hyperammonemia: what urea-lly need to know: case report of severe noncirrhotic hyperammonemic encephalopathy and review of the literature. Case Rep. Med. 2016, 8512721 (2016).
4. Mew, N. A., Pappa, M. B., Gropman, A. L. in Rosenberg’s Molecular and Genetic Basis of Neurological and Psychiatric Disease (eds Rosenberg, R. N. & Pascual, J. M.) 633–647 (Elsevier, 2014).
5. Najafi, R. et al. Demographic and clinical findings in pediatric patients affected by organic acidemia. Iran. J. Child. Neurol. 10, 74–81 (2016).
Cited by
60 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献