Biodegradable polymer-based interleukin-12 gene delivery: role of induced cytokines, tumor infiltrating cells and nitric oxide in anti-tumor activity

Author:

Maheshwari A,Han S,Mahato RI,Kim SW

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Reference42 articles.

1. Brunda MJ et al. Antitumor and antimetastatic activity of interleukin-12 against murine tumors J Exp Med 1993 178: 1223–1230

2. Rakhmilevich AL et al. Cytokine gene therapy of cancer using gene gun technology: superior antitumor activity of interleukin-12 Hum Gene Ther 1997 8: 1303–1311

3. Tahara H et al. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector J Immunol 1995 154: 6466–6474

4. Smyth MJ, Taniguchi M, Street SEA . The anti-tumor activity of IL-12: mechanisms of innate immunity that are model and dose dependent J Immunol 2000 165: 2665–2670

5. Fernandez NC et al. High frequency of specific CD8+ T cells in the tumor and blood is associated with efficient local IL-12 gene therapy of cancer J Immunol 1999 162: 609–617

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