Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein

Author:

Vinyals A,Peinado M A,Gonzalez-Garrigues M,Monzó M,Bonfil R D,Fabra A

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Reference59 articles.

1. Greenblatt MS, Bennett WP, Hollstein M, Harris CC . Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis Cancer Res 1994 54: 4855–4878

2. Sidransky D, Hollstein M . Clinical implications of the p53 gene Annu Rev Med 1996 47: 285–301

3. Finlay CA . The mdm-2 oncogene can overcome wild-type p53 suppression of transformed cell growth Mol Cel Biol 1993 13: 301–306

4. Knippschild U, Oren M, Deppert W . Abrogation of wild-type p53 mediated growth-inhibition by nuclear exclusion Oncogene 1996 12: 1755–1765

5. Farmer G et al. Wild-type p53 activates transcription in vitro Nature 1992 358: 83–86

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