Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor–avidin fusion protein

Author:

Lehtolainen P,Wirth T,Taskinen A K,Lehenkari P,Leppänen O,Lappalainen M,Pulkkanen K,Marttila A,Marjomäki V,Airenne K J,Horton M,Kulomaa M S,Ylä-Herttuala S

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Reference38 articles.

1. Wilchek M, Bayer EA . Introduction to avidin–biotin technology. Methods Enzymol 1990; 184: 5–13.

2. Breitz HB et al. Clinical optimization of pretargeted radioimmunotherapy with antibody–streptavidin conjugate and 90Y-DOTA-biotin. J Nucl Med 2000; 41: 131–140.

3. Penichet ML et al. An antibody–avidin fusion protein specific for the transferrin receptor serves as a delivery vehicle for effective brain targeting: initial applications in anti-HIV antisense drug delivery to the brain. J Immunol 1999; 163: 4421–4426.

4. Axworthy DB, Reno JM, Hylarides MD et al. Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity. Proc Natl Acad Sci USA 2000; 97: 1802–1807.

5. Green RM . Avidin. Adv Protein Chem 1975; 29: 85–133.

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