Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3

Author:

van der Laan W H,Quax P H A,Seemayer C A,Huisman L G M,Pieterman E J,Grimbergen J M,Verheijen J H,Breedveld F C,Gay R E,Gay S,Huizinga T W J,Pap T

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Reference36 articles.

1. Zvaifler NJ et al. Pannocytes distinctive cells found in rheumatoid arthritis articular cartilage erosions. Am J Pathol 1997; 150: 1125–1138.

2. Müller-Ladner U et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996; 149: 1607–1615.

3. Harris ED . Etiology and Pathogenesis of Rheumatoid Arthritis, Vol.4, W.B. Saunders Company: Philadelphia, 1993, pp 833–873.

4. Van der Laan WH et al. Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. Arthritis Rheum 2000; 43: 1710–1718.

5. Case JP et al. Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes. Am J Pathol 1989; 135: 1055–1064.

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