Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1

Author:

Shen J,Samul R,Silva R L,Akiyama H,Liu H,Saishin Y,Hackett S F,Zinnen S,Kossen K,Fosnaugh K,Vargeese C,Gomez A,Bouhana K,Aitchison R,Pavco P,Campochiaro P A

Publisher

Springer Science and Business Media LLC

Subject

Genetics,Molecular Biology,Molecular Medicine

Reference28 articles.

1. Okamoto N, Tobe T, Hackett SF, Ozaki H, Vinores MA, LaRochelle W et al. Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization. Am J Pathol 1997; 151: 281–291.

2. Seo M-S, Kwak N, Ozaki H, Yamada H, Okamoto N, Yamada E et al. Dramatic inhibition of retinal and choroidal neovascularization by oral administration of a kinase inhibitor. Am J Pathol 1999; 154: 1743–1753.

3. Ozaki H, Seo M-S, Ozaki K, Yamada H, Yamada E, Okamoto N et al. Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization. Am J Pathol 2000; 156: 679–707.

4. Kwak N, Okamoto N, Wood JM, Campochiaro PA . VEGF is an important stimulator in a model of choroidal neovascularization. Invest Ophthalmol Vis Sci 2000; 41: 3158–3164.

5. Gragoudas ES, Adamis AP, Cunningham Jr ET, Feinsod M, Guyer DR . Pegaptanib for neovascular age-related macular degeneration. N Engl J Med 2004; 351: 2805–2816.

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