Caspase-3 cleaves Apaf-1 into an ∼30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive ∼1.4 MDa apoptosome complex
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/4400834.pdf
Reference29 articles.
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3. Earnshaw WC, Martins LM, Kaufmann SH . 1999 Mammalian caspases: structure, activation, substrates, and functions during apoptosis Annu. Rev. Biochem. 68: 383–424
4. Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR, Cohen GM . 1999 Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis J. Biol. Chem. 274: 5053–5060
5. Nicholson DW . 1999 Caspase structure, proteolytic substrates, and function during apoptotic cell death Cell Death Differ. 6: 1028–1042
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