Non-destructive crystallinity assessment of indomethacin in tablets made from smartFilms® using terahertz time-domain spectroscopy

Abstract

AbstractWe use terahertz (THz) time-domain spectroscopy (TDS) to assess the crystalline state of indomethacin (IM) when loaded in smartFilms®. We found that smartFilms favour the amorphous IM (A-IM) for low loading concentrations. For higher concentrations, IM recrystallizes in its $$\alpha$$ α - crystalline form and the amount of A-IM in the smartFilms reduces. Both, $$\alpha$$ α - and A-IM are preferred over the more common $$\gamma$$ γ - crystalline form, as they exhibit better water solubility, which can increase the oral bioavailability of the drug.